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Prednisone is a type of corticosteroid that is often prescribed by doctors to treat many inflammatory conditions, including inflammatory bowel disease (IBD)and Crohn's disease. In a 2013 study, researchers at the University of Wisconsin-Madison, published in the Annals of Internal Medicine, found that chronic NSAID use had a direct impact on the immune system of patients with IBD. Researchers hypothesized that the increase in inflammation could have been a contributing factor to the increased rates of Crohn's disease, ulcerative colitis and other inflammatory diseases. Now, in a new study published in the June 25 online issue of JAMA Gastroenterol Hepatol, researchers from the University of Maryland School of Medicine analyzed data from over 18,000 adults ages 25-74 in North Carolina, Georgia, Tennessee, and Puerto Rico. During 2008-2015, researchers analyzed data from almost 22,000 participants. The researchers found that NSAIDs were linked to higher rates of colitis in the participants. Previous research has shown that colitis patients had a high likelihood of taking statins, ibuprofen, paracetamol, or other painkillers, but not NSAIDs or antibiotics. In 2014, a systematic literature review and meta-analysis showed that NSAIDs could increase the risk of colitis and Crohn's disease by about 40 percent, while ibuprofen and paracetamol may only increase the risk by about 8-9 percent. "Our study shows that NSAIDs may increase the risk of Crohn's disease by a whopping 85 percent and ulcerative colitis by a whopping 100 percent," Dr. John Cavanagh, one of the study's authors and associate professor of medicine at the University of Maryland School of Medicine, said in a news release. "We need to make sure our patients know what they're getting into, and we need to know more about the interactions between different NSAIDs." The team used data from the National Health Interview Survey (1988-2012) and the Current Population Survey of the National Centre for Health Statistics (2010-2014) as well as data from the National Health and Nutrition Examination Survey 2013-2014. Overall, the researchers found that the rates of colon and Crohn's disease rose among participants taking NSAIDs or other NSAIDs, but there was no association among those taking ibuprofen, acetaminophen, or acetaminophen and the other non-NSAIDs. Researchers also noted that the association was not as large among participants taking the NSAIDs alone. Follow Elizabeth Palermo @techEpalermo. Follow Live Science @ Similar articles: